MS 154N - CAS 2675490-97-6

MS 154N is a negative control for MS 154. The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kdvalues are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

Others, PROTACs, EGFR

PROTAC, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Others, Angiogenesis

2675387

C47H56ClFN8O8

915.45

O=C1C=2C(C(=O)N1C3C(=O)N(C)C(=O)CC3)=CC=CC2OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(C=C5OC)N=CN=C6NC7=CC(Cl)=C(F)C=C7)CC4)=O

-20°C

Ice Packs

Small Compound