MS143 - CAS 2376137-41-4

MS143, a potent AKT degrader (DC50=46 nM and GI50=0.8 μM in PC3 cells), effectively induces AKT degradation through the ubiquitin-proteasome system in both a concentration- and time-dependent manner, leading to the suppression of cancer cell growth [1].

Akt, PROTACs, Others

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, PROTAC, Others

2376092

C59H81ClN12O6S

1121.87

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)N2CCN(CC[C@H](NC(=O)C3(N)CCN(CC3)c3ncnc4[nH]ccc34)c3ccc(Cl)cc3)CC2)C(C)(C)C)cc1

-20°C

Ice Packs

Small Compound