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Molfinity

MS5033 - CAS 2376137-29-8

MS5033 - CAS 2376137-29-8

MF-0154658-01

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Product Details

  • Bioactivity

    MS5033 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades AKT (also known as protein kinase B), exhibiting a half-maximal degradation concentration (DC50) of 430 nM in PC3 cells [1].

  • Target

    Others, Akt, PROTACs

  • Related Pathways

    PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, PROTAC, Others

  • CAS Number

    2376100

  • Molecular Formula

    C51H66ClN11O11

  • Molecular Weight

    1044.59

  • SMILES

    NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)N[C@@H](CCN1CCN(CC1)C(=O)CCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc(Cl)cc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    PROTAC