MS8815 - CAS 2855085-25-3

MS8815, a selective proteolysis targeting chimera (PROTAC) degrader of enhancer of zeste homolog 2 (EZH2), exhibits inhibitory activity with an IC50 value of 8.6 nM. It is utilized in the research of triple-negative breast cancer (TNBC) [1].

PROTACs, Histone Methyltransferase

Chromatin/Epigenetic, PROTAC

2855057

C65H87N9O8S

1154.51

CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCN(CC2)C(=O)CCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)cc1

-20°C

Ice Packs

PROTAC