MS8847 - CAS 3050872-59-5

MS8847 is a potent EZH2PROTAC degrader that recruits the E3 ligase von Hippel-Lindau (VHL) . It degrades EZH2 efficiently through a ubiquitin-proteasome system-dependent mechanism. MS8847 effectively inhibits the growth of acute myeloid leukemia (AML) and triple-negative breast cancer (TNBC) cells.

PROTACs, Histone Methyltransferase

PROTAC, Chromatin/Epigenetic

3050808

C70H98N10O8S

1239.65

N(CC)(C1=CC(=CC(C(NCC2=C(C)C=C(C)NC2=O)=O)=C1C)C3=CC=C(CN4CCN(CCC(NCCCCCCCCCCC(N[C@H](C(=O)N5[C@H](C(NCC6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5)[C@](C)(C)C)=O)=O)CC4)C=C3)C8CCOCC8

-20°C

Ice Packs

PROTAC