MS9449 - CAS 2772612-96-9

MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways, robustly suppressing the proliferation of NSCLC cells, indicating its potential utility in anticancer research [1].

EGFR, PROTACs

PROTAC, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2772507

C60H76ClFN10O8S

1151.82

N(C=1C2=C(C=C(OC)C(OCCCN3CCN(C(CCCCCCCCCCNC(C[C@H](NC(=O)[C@H]4N(C([C@H]([C@H](C)C)C=5ON=C(C)C5)=O)C[C@H](O)C4)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)=O)CC3)=C2)N=CN1)C8=CC(Cl)=C(F)C=C8

-20°C

Ice Packs

PROTAC