MT477 - CAS 328069-91-6

MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.

PKC, Others

Chromatin/Epigenetic, Others, Cytoskeletal Signaling

327972

C31H30N2O12S3

718.77

C(OC)(=O)C=1C2(C=3C=4C(N(C(CN5C(=O)CCC5=O)=O)C(C)(C)C3SC1C(OC)=O)=C(OC)C=CC4)SC(C(OC)=O)=C(C(OC)=O)S2

-20°C

Ice Packs

Small Compound