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Molfinity

MTK458 - CAS 2499962-58-0

MTK458 - CAS 2499962-58-0

MF-0095314-01

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Product Details

  • Bioactivity

    MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.

  • Target

    Mitochondrial Metabolism, Mitophagy, PTEN

  • Related Pathways

    Metabolism, Autophagy, PI3K/Akt/mTOR signaling

  • CAS Number

    2499904

  • Purity

    0.9836

  • Molecular Formula

    C17H15F3N4

  • Molecular Weight

    332.32

  • SMILES

    N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound