MTX-216 - CAS 1952236-19-9

MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.

Syk, Apoptosis, PI3K, EGFR

JAK/STAT signaling, Angiogenesis, PI3K/Akt/mTOR signaling, Apoptosis, Tyrosine Kinase/Adaptors

1952208

C22H14Cl2FN5O2S

502.348

N#CC=1C=NC2=CC=C(C=C2C1NC3=CC=C(F)C(Cl)=C3)C=4C=NC(Cl)=C(C4)NS(=O)(=O)C

-20°C

Ice Packs

Small Compound