Multi-kinase inhibitor 3 - CAS 2648279-76-7

Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.

PDGFR, VEGFR, FLT

Angiogenesis, Tyrosine Kinase/Adaptors

2648196

C26H26N6O2

454.52

O=C(NC=1ON=C(C1)C(C)(C)C)CC2=CC=C(C=C2)N3C=NC=4C=C(C=CC43)C=5C=NN(C5)C

-20°C

Ice Packs

Small Compound