Murrangatin - CAS 37126-91-3

Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277) . Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9±6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1β, tumor necrosis factorα, prostaglandins E2, and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2.

Prostaglandin Receptor, COX, IL Receptor, TNF

Apoptosis, Neuroscience, GPCR/G Protein, Immunology/Inflammation

37032

C15H16O5

276.28

COc1ccc2ccc(=O)oc2c1[C@@H](O)[C@@H](O)C(C)=C

-20°C

Ice Packs

Natural Product