MYF-03-176 - CAS 2857937-59-6

MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC50 values of 47/32/71 nM, respectively. It also inhibits TEAD transcriptional activity and cell growth in NCI-H226 cells, exhibiting antitumour activity in malignant pleural mesothelioma (MPM) cells with defective Hippo signalling and in mouse xenograft models.

YAP

Stem Cells

2857872

C19H18F4N4O2

410.37

O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@H](NC=3N=CC=CN3)CN(C(C(=C)F)=O)C2

-20°C

Ice Packs

Small Compound