MYF-03-69 - CAS 2416418-11-4

MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC50 values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC50 = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM) .

YAP, Cell Cycle Arrest, Apoptosis

Cell Cycle/Checkpoint, Apoptosis, Stem Cells

2416403

C22H20F3N5O2

443.42

O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@@H](CN(C(C=C)=O)C2)N3C=C(N=N3)C=4C=CC=NC4

-20°C

Ice Packs

Small Compound