N-Arachidonoyl Taurine - CAS 119959-65-8

N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12 (S) - and 15 (S) -lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 μM, respectively) . It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 μM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells. The levels of N-arachidonoyl taurine are changed in mouse brain following administration of δ9-tetrahydrocannabinol (δ9-THC) .

Others, TRP/TRPV Channel

Others, Membrane transporter/Ion channel

119886

C22H37NO4S

411.6

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCS(O)(=O)=O

-20°C

Ice Packs

Small Compound