N-butyl Lithocholic Acid - CAS 135013-42-2

N-butyl Lithocholic acid is a derivative of the secondary bile acid lithocholic acid. Lipid nanoparticles containing N-butyl Lithocholic acid and encapsulating mRNA vaccines that express hemagglutinin show reduced cardiotoxicity, splenic, and hepatic toxicity in mice compared to lipid nanoparticles that contain cholesterol.

Endogenous Metabolite

Metabolism

134969

C28H48O3

432.68

C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(OCCCC)=O)C)[H])[H]

-20°C

Ice Packs

Inhibitors & Agonists