N-Desethyl Sunitinib - CAS 356068-97-8

N-Desethyl Sunitinib (SU012662) is the primary active metabolite of Sunitinib produced by the metabolism of cytochrome P450 enzyme 3A4 (CYP3A4) .Sunitinib is an orally available inhibitor of a number of tyrosine kinases involved in tumor proliferation and angiogenesis, including VEGFR, PDGFR, KIT, and FLT3, and was approved for the treatment of advanced/metastatic renal cell carcinoma (RCC)

C-Kit, PDGFR, Drug Metabolite, VEGFR, FLT

Metabolism, Tyrosine Kinase/Adaptors, Angiogenesis

355963

C20H23FN4O2

370.42

C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCNCC)=O)=C(C)N3

-20°C

Ice Packs

Small Compound