N-desmethyl Regorafenib N-oxide - CAS 835621-12-0

N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.

Drug Metabolite, c-Kit, Others, Raf, VEGFR

Others, Angiogenesis, Tyrosine Kinase/Adaptors, Metabolism, MAPK

835621-12-0

C20H13ClF4N4O4

484.79

O(C=1C=C(C(N)=O)N(=O)=CC1)C2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2

-20°C

Ice Packs

Small Compound