N-Didesmethyladitoprim - CAS 56066-19-4

N-Didesmethyladitoprim is a metabolite of Aditoprim, which acts as a selective inhibitor of bacterial dihydrofolate reductase (DHFR) . Aditoprim exhibits inhibitory concentration (IC50) values of 47 nM for Escherichia coli and 520 nM for Lactobacillus casei DHFR. It impedes the reduction of dihydrofolate to tetrahydrofolate. Aditoprim demonstrates broad-spectrum antibacterial activity and excellent pharmacokinetics.

Antifolate, Drug Metabolite, Antibacterial

Cell Cycle/Checkpoint, Microbiology/Virology, Metabolism

56043

C13H17N5O2

275.31

N=1C=C(C(=NC1N)N)CC2=CC(OC)=C(N)C(OC)=C2

-20°C

Ice Packs

Small Compound