N-Fmoc-8-aminooctanoic acid - CAS 126631-93-4

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Others, PROTAC Linker

Others, PROTAC

126534

C23H27NO4

381.46

C(OC(NCCCCCCCC(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

-20°C

Ice Packs

PROTAC