N-piperidine Ibrutinib - CAS 330785-90-5

N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

BTK, Ligands for Target Protein for PROTAC

Angiogenesis, PROTAC, Tyrosine Kinase/Adaptors

330690

0.9665

C22H22N6O

386.45

NC1=C2C(=NN(C2=NC=N1)C3CCNCC3)C4=CC=C(OC5=CC=CC=C5)C=C4

-20°C

Ice Packs

PROTAC