N3-PEG3-VC-PAB-MMAF - CAS 2757277-32-8

N3-PEG3-VC-PAB-MMAF (Comp T-88-5) is a drug-linker conjugate for antibody-drug conjugates (ADCs) comprising the ADC linker N3-PEG3-VC-PAB and the microtubule-disrupting agent MMAF [1]. This click chemistry reagent features an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules and can also perform strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds presenting DBCO or BCN groups.

Drug-Linker Conjugates for ADC

Antibody-drug Conjugate/ADC Related

2757277-32-8

C66H105N13O17

1352.62

[C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC(COCCOCCOCCN=[N+]=[N-])=O)[C@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)C(C)C)=O)[C@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]

-20°C

Ice Packs

Small Compound