NA-17 - CAS 1708948-28-0

NA-17 is a naphthalimide compound with antitumor activity and exhibits lower toxicity to normal cells such as HL-7702 and WI-38. It demonstrates p53-dependent inhibition selectivity in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of these cells. NA-17 causes cell cycle arrest in the G1 phase and promotes apoptosis and cell death.

MDM-2/p53, Apoptosis

Apoptosis

1708920

C26H27N3O4

445.51

O=C1C2=CC=CC=3C(=CC=C(C(=O)N1CCC4=CC=C5OCOC5=C4)C23)NCCCN(C)C

-20°C

Ice Packs

Small Compound