NAMPT activator-6 - CAS 2237267-86-4

NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].

NAMPT

Metabolism

2237267-86-4

C17H21N5O3S

375.45

S(=O)(=O)(C1=CC=C(NC(NCC=2C=CN=CC2)=O)C=C1)N3CCNCC3

-20°C

Ice Packs

Small Compound