NAMPT inhibitor-linker 2 - CAS 2241014-82-2

NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrates potent efficacy against c-Kit expressing cell lines, including GIST-T1 and NCI-H526, with IC50 values of <7 pM and 40 pM, respectively.

NAMPT, Drug-Linker Conjugates for ADC

Metabolism, Antibody-drug Conjugate/ADC Related

2240930

C34H33FN6O5

624.66

C(NC1=CC(F)=C(CNC(=O)C2=CC=C(C=C2)N3CCN(C(CCN4C(=O)C=CC4=O)=O)CC3)C=C1)(=O)[C@@H]5[C@H](C5)C=6C=CC=NC6

-20°C

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