Nav1.8-IN-20 - CAS 3024470-62-7

Nav1.8-IN-20 (Compound I) is an orally active inhibitor of the voltage-gated sodium channel Nav1.8, with an IC50 value of 14 nM. It effectively blocks the generation and propagation of action potentials in peripheral nociceptive neurons, providing analgesic effects. Nav1.8-IN-20 shows potential for research in several pain types, including acute, chronic, inflammatory, and neuropathic pain.

Sodium Channel

Membrane transporter/Ion channel

3024401

C18H10Cl2F3N3O4

460.19

O=C(NC1=CN=CN(=O)=C1)C2=CC(Cl)=C(Cl)C=C2OC3=CC=C(OC(F)(F)F)C=C3

-20°C

Ice Packs

Small Compound