Nav1.8-IN-7 - CAS 2761181-58-0

Nav1.8-IN-7 (Example 116) serves as a selective inhibitor of Nav1.8, demonstrating more than 50% inhibition at 100 nM specifically for Nav1.8. It exhibits an IC50 of 15.6 μM for the hERG channel. This compound holds promise in the field of pain research [1].

Sodium Channel, Potassium Channel

Membrane transporter/Ion channel

2761181-58-0

C22H18ClF4N3O5

515.84

O(C1=C(C(NC=2C=C(OC[C@@H](CO)O)N=NC2)=O)C=C(Cl)C(C(F)(F)F)=C1)C3=C(C)C=C(F)C=C3

-20°C

Ice Packs

Small Compound