Molfinity

Navtemadlin - CAS 1352066-68-2

SKU:MF-0096621-01

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Product Details

Bioactivity
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM) . It binds to MDM2 with a Kd of 0.045 nM.
Target
MDM-2/p53, Mdm2, E1/E2/E3 Enzyme
Related Pathways
Ubiquitination, Apoptosis
CAS Number
1351996
Purity
0.9908
Molecular Formula
C28H35Cl2NO5S
Molecular Weight
568.55
SMILES
CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound