NAZ2329 - CAS 2809469-05-2

NAZ2329 is the first cell-permeable inhibitor of the R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), which is a variant and preferentially inhibits PTPRZ (IC50=7.5 μM for hPTPRZ1) and PTPRG (IC50=4.8 μM for hPTPRG) compared to other PTPs. NAZ2329 inhibited the tumor growth of glioblastoma cells and exhibited stem cell-like properties compared to the whole (D1 + D2) fragment of PTPRZ.

Others, Phosphatase

Metabolism, Others

2809469-05-2

C21H18F3NO4S3

501.56

S(CC1=C(OCC)C=CC(C(F)(F)F)=C1)C2=C(C(NS(=O)(=O)C3=CC=CC=C3)=O)SC=C2

-20°C

Ice Packs

Small Compound