NBC 6 - CAS 2068818-02-8

NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor with an IC50 of 574 nM. It acts independently of Ca 2+ and inhibits Nigericin-induced inflammasome activation in THP-1 cells, as well as Imiquimod-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) [1].

NOD-like Receptor (NLR), Others

Immunology/Inflammation, Others

2068818-02-8

C18H16BCl3N2O2

409.5

C(Cl)(Cl)(Cl)C1=[NH][B+3](O=C(N)[C-]1C(C)=O)([C-]=2C=CC=CC2)[C-]=3C=CC=CC3

-20°C

Ice Packs

Small Compound