NBI 35965 hydrochloride - CAS 1782228-59-4

NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].

CRFR

GPCR/G Protein

1782228-59-4

C21H23Cl3N4

437.79

C(N1C2=C3C(C(=NN3C[C@@H]1CC)C4=C(Cl)C=C(Cl)C=C4)=NC(C)=C2)C5CC5.Cl

-20°C

Ice Packs

Small Compound