NBI-74330 - CAS 855527-92-3

NBI-74330 is a high-affinity CXCR3 antagonist that inhibits the binding of CXCR3 to its ligands CXCL10 and CXCL11, reduces the formation of atherosclerotic plaques in LDL receptor-deficient mice, and decreases the migration of CD4+ T cells and macrophages to the peritoneum.

CXCR

Autophagy, Immunology/Inflammation, GPCR/G Protein

855432

0.9937

C32H27F4N5O3

605.58

[C@@H](N(CC=1C=CC=NC1)C(CC2=CC(C(F)(F)F)=C(F)C=C2)=O)(C)C=3N(C(=O)C=4C(N3)=NC=CC4)C5=CC=C(OCC)C=C5

-20°C

Ice Packs

Small Compound