NBTI 5463 - CAS 1227303-03-8

NBTI 5463 is a bacterial type II topoisomerase (topoisomerase II) inhibitor with antimicrobial properties. It effectively inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. By binding to topoisomerase II, NBTI 5463 prevents DNA cleavage and re-ligation, thereby impeding bacterial DNA replication and transcription. This compound shows potential for research into Gram-negative bacterial infections.

Antibacterial, Topoisomerase

DNA Damage/DNA Repair, Microbiology/Virology

1227303-03-8

C25H30N6O4

478.54

C([C@H](N)[C@]1(CC[C@H](NCC=2N=C3C(=CC2)OCC(=O)N3)CC1)[H])N4C=5C(C=CC4=O)=NC=C(OC)C5

-20°C

Ice Packs

Small Compound