NC-III-49-1 - CAS 3031654-46-0

NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for various BRD4 and BRDT isoforms, as demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].

Others, Epigenetic Reader Domain

Others, Chromatin/Epigenetic

3031608

C44H50N4O11S2

875.02

CN(C1=O)C=C(C2=CC(NS(CC)(=O)=O)=CC=C2OCCOCCOCCOCCOC3=CC=C(NS(CC)(=O)=O)C=C3C(C4=C5C=CC=C4)=CN(C)C5=O)C6=C1C=CC=C6

-20°C

Ice Packs

Small Compound