NCI-006 - CAS 1964516-64-0

NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.

ROS, Others, Apoptosis, Dehydrogenase

Apoptosis, Immunology/Inflammation, Metabolism, Others

1964452

C31H24F2N4O4S3

650.74

C(C1=C(CC2CC2)N(N=C1C3=CC(C#CC=4SC(C)=CC4)=C(F)C=C3)C5=NC(C(O)=O)=CS5)C6=CC(F)=C(S(N)(=O)=O)C=C6

-20°C

Ice Packs

Small Compound