NCI677397 - CAS 907547-06-2

NCI677397 is a USP24 inhibitor. It enhances lipid ROS, activates cholesterol and fatty acid biosynthesis, and degrades ABC transporters, GPX4, and DHFR through the autophagy pathway. This process reduces p-gp levels, ultimately leading to ferroptosis in drug-resistant cancer cells. NCI677397 is relevant for research in lung and brain cancers.

Glutathione Peroxidase, DUB, ROS, Ferroptosis, Autophagy

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Ubiquitination, Autophagy, Immunology/Inflammation, Metabolism, Apoptosis

907547-06-2

C28H31N3OS

457.63

O=C(C=1C=CC=CC1)C2=CC=C3SC=4C=CC=CC4N(C3=C2)CCCCN5CCN(C)CC5

-20°C

Ice Packs

Small Compound