NDM-1 inhibitor-7 - CAS 26151-73-5

NDM-1 inhibitor-7 (Compound A8) is an NDM-1 inhibitor with an IC50 of 10.284 μM. It restores the ability of meropenem (MEM) to penetrate the cell wall of Gram-negative bacteria and effectively reinstates MEM's antibacterial activity against NDM-1 positive Escherichia coli. Moreover, NDM-1 inhibitor-7 demonstrates significant efficacy in both Galleria mellonella and murine peritonitis infection models.

Beta-lactamase, Antibacterial

Microbiology/Virology

26073

C9H10N2OS2

226.319

S=C(SC)NN=CC=1C=CC=CC1O

-20°C

Ice Packs

Small Compound