Nebentan - CAS 403604-85-3

Nebentan (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].

Others, Endothelin Receptor

GPCR/G Protein, Others

403604-85-3

C24H21N5O5S

491.52

COc1ccccc1Oc1c(NS(=O)(=O)\C=C\c2ccccc2)nc(nc1OC)-c1ncccn1

-20°C

Ice Packs

Small Compound