NecroX-7 - CAS 1120332-55-9

NecroX-7 (LC-280126) is a potent free radical scavenger and HMGB1 (high-mobility group box 1) inhibitor. It serves as an antidote to acetaminophen toxicity and exerts a protective effect by preventing HMGB1 release in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits HMGB1-induced release of TNF and IL-6 and the expression of TLR-4 and receptor for advanced glycation end products. This compound may be used for graft-versus-host disease (GVHD) research [1].

TNF, NADPH-oxidase, Reactive Oxygen Species, TLR, Interleukin, ROS

Metabolism, Immunology/Inflammation, NF-κB, Apoptosis

1120268

0.9822

C24H29N3O3S

439.57

N(C1=C2C(C=C(N2)C3=CC=CC=C3)=CC(CN4CCS(=O)(=O)CC4)=C1)C5CCOCC5

-20°C

Ice Packs

Small Compound