Neospiramycin I - CAS 70253-62-2

Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus (MICs = 3.12 and >100 μg/ml, respectively), as well asB. cereus, B. subtilis, M. luteus, E. coli, andK. pneumoniae (MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively) . Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 μM. It protects against mortality in a mouse model ofS. pneumoniaetype III infection (ED50= 399.8 mg/kg) .2

Others, Antibacterial, Antibiotic

Others, Microbiology/Virology

70189

C36H62N2O11

698.895

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-20°C

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Small Compound