NEP162 - CAS 3031840-36-2

NEP162 is a BRD4 PROTAC degrader with DC50 values of 1.2 μM in SW480 cells and 1.6 μM in U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibiting tumor growth and inducing apoptosis. It is applicable in research on cancers such as osteosarcoma, colorectal cancer, and non-small cell lung cancer.

Apoptosis, PROTACs, Epigenetic Reader Domain

Chromatin/Epigenetic, Apoptosis, PROTAC

3031802

C50H56ClN11O3S

926.57

CC=1C2=C(N3C([C@H](CC(=O)N4CCN(CCCOC=5C=C6C(=CC5)N=C(N6)[C@@H]7CC[C@H](NC(CNCC8=CC=9C(N8)=CC=CC9)=O)CC7)CC4)N=C2C%10=CC=C(Cl)C=C%10)=NN=C3C)SC1C

-20°C

Ice Packs

PROTAC