Neuroprotective agent 11 - CAS 3081915-81-0

Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53) . Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.

MDM-2/p53, COX, Caspase, NO Synthase

Neuroscience, Apoptosis, Immunology/Inflammation, Proteases/Proteasome

3081834

C32H30O12

606.57

O[C@H]1[C@@H](C=2C(O[C@@H]1C3=CC(O)=C(O)C=C3)=C(CC)C(O)=CC2O)C4=C5C(C[C@H](O)[C@H](O5)C6=CC(O)=C(O)C=C6)=C(O)C=C4O

-20°C

Ice Packs

Small Compound