Neuroprotective agent 12 - CAS 2522599-69-3

Neuroprotective agent 12 is an orally active compound capable of crossing the blood-brain barrier, offering significant neuroprotective properties. It exhibits robust antioxidant and anti-inflammatory effects, markedly inhibiting cell death induced by glutamate and acrolein. This agent reduces the expression of PDE4B while elevating levels of HO-1, p-CREB, and BDNF. In a traumatic brain injury (TBI) mouse model, Neuroprotective agent 12 demonstrates potent neuroprotection and holds potential for research into TBI and other central nervous system disorders.

ROS, PDE, NF-κB

NF-κB, Immunology/Inflammation, Metabolism

2522527

C23H28N2O3

380.48

O(C1=C(OC)C=C(/C=C/C(NC2=CC=C(N(C)C)C=C2)=O)C=C1)C3CCCC3

-20°C

Ice Packs

Small Compound