NF-κB-IN-1 - CAS 1227098-15-8

NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis (3,4-dimethoxyphenyl) -4-[ (4-hydroxy-3-methoxyphenyl) methylene]-, (1E,6E) -) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.

IκB/IKK, NF-κB

NF-κB

1227075

0.9929

C31H30O8

530.57

COc1ccc(\C=C\C(=O)C(=Cc2ccc(O)c(OC)c2)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC

-20°C

Ice Packs

Small Compound