NF-κB-IN-11 - CAS 2768833-35-6

NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and nuclear translocation of NF-κB, alongside reducing expression levels of phospho-IKK, IκBα, and NF-κB p65. Demonstrating anti-inflammatory properties, it mitigates dextran sulfate sodium-induced colitis in mice and exhibits a maximum tolerated dose (MTD) exceeding 1852 mg/kg in acute toxicity assays when administered orally (p.o.) [1].

NF-κB

NF-κB

2768792

C19H18O5

326.34

C(OC)(=O)C=1C2C(C#CC3=CC=C(C)C=C3)CC(O2)C1C(OC)=O

-20°C

Ice Packs

Small Compound