NF-κB-IN-14 - CAS 3019972-01-8

NF-κB-IN-14 (compound 5e) inhibits nitric oxide production in macrophages induced by LPS, with an IC50 of 6.4 μM. It disrupts the interaction between TLR4 and MyD88 proteins, thereby inhibiting the NF-κB signaling pathway. Additionally, NF-κB-IN-14 reduces ear edema and inflammation in a mouse model of atopic dermatitis.

NF-κB, TLR

Immunology/Inflammation, NF-κB

3019972-01-8

C15H12Cl2N4

319.19

C(/C=C/C1=CC=C(C)C=C1)N2C=3C(N=C2)=C(Cl)N=C(Cl)N3

-20°C

Ice Packs

Small Compound