NF (N-Me) GA (N-Me) IL - CAS 409085-42-3

NF (N-Me) GA (N-Me) IL is a biologically active peptide, representing a modified segment (amino acids 22 to 27) of the human islet amyloid polypeptide (hIAPP) sequence NFGAIL. This modification includes N-methylations at G24 and I26, transforming the amyloidogenic and cytotoxic nature of the original sequence into a non-amyloidogenic and non-cytotoxic variant. Moreover, the peptide maintains the ability to bind with high affinity to full-length hIAPP, effectively inhibiting its fibril formation.

409085-42-3

C32H51N7O8

661.79

[C@H](CC1=CC=CC=C1)(C(N(CC(N[C@H](C(N([C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@H](CC)C)C)=O)C)=O)C)=O)NC([C@H](CC(N)=O)N)=O

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