NF449 - CAS 389142-38-5

NF449 is a potent antagonist of the P2X1 receptor, displaying IC50 values of 0.28 nM, 0.69 nM, and 120 nM for rP2X1, rP2X1+5, and P2X2+3, respectively. It acts selectively against Gsα G proteins (G Protein) . NF449 inhibits the binding rate of GTP[γS] to Gsα-s, suppresses the stimulation of adenylate cyclase activity, and blocks the coupling of β-adrenergic receptors with Gs.

P2X Receptor

Neuroscience, Membrane transporter/Ion channel

389099

C41H32N6O29S8

1329.24

O=C(NC=1C=C(C=C(C1)C(=O)NC2=CC=C(C=C2S(=O)(=O)O)S(=O)(=O)O)C(=O)NC3=CC=C(C=C3S(=O)(=O)O)S(=O)(=O)O)NC=4C=C(C=C(C4)C(=O)NC5=CC=C(C=C5S(=O)(=O)O)S(=O)(=O)O)C(=O)NC6=CC=C(C=C6S(=O)(=O)O)S(=O)(=O)O

-20°C

Ice Packs

Small Compound