NH2-methylpropanamide-Exatecan TFA - CAS 1817857-35-4

Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL), utilized in the synthesis of ADCs for cancer research [1].

Topoisomerase, ADC Cytotoxin

DNA Damage/DNA Repair, Antibody-drug Conjugate/ADC Related

1817818

C30H30F4N4O7

634.58

C(C(O)=O)(F)(F)F.N(C([C@H](CN)C)=O)[C@@H]1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6

-20°C

Ice Packs

Small Compound