NHI-2 - CAS 1269802-97-2

NHI-2 is a lactate dehydrogenase A (LDHA) inhibitor with an IC50 value of 14.7 μM, demonstrating high selectivity for LDHA over LDHB, for which the IC50 is 55.8 μM. NHI-2 functions as an efficient anti-glycolytic agent, enhancing apoptosis, inducing cell cycle arrest at the S and G2 phases, and exerting broad-spectrum antiproliferative effects in cancer cells. NHI-2 additionally affects extracellular acidification rates and ATP production and has demonstrated tumor growth suppression in murine B78 melanoma models, highlighting its role in cancer metabolism research.

Apoptosis, Dehydrogenase

Apoptosis, Metabolism

1269703

0.99981

C17H12F3NO3

335.28

C(F)(F)(F)C1=C2C(N(O)C(C(OC)=O)=C2)=CC(=C1)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound