NHTD - CAS 2540915-70-4

NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis) . NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC) .

PDE, Ras

MAPK, GPCR/G Protein, Metabolism

2540841

C24H26N2O5

422.47

C(=N/NC(=O)C1=C(O)C=C(O)C=C1)\C2=C3C(OC4=C3CCCC4)=CC(C(C)(C)C)=C2O

-20°C

Ice Packs

Small Compound